New Brunswick Scientific has introduced a new
benchtop cell culture bioreactor that combines single-
use technology with the trusted performance and true
scalability of a stirred-tank design.
CelliGen BLU has been engineered for high-density
animal cell culture in research or production, using
interchangeable, single-use, stirred-tank vessels in
5.0 and 14.0 L total volume capacities. A compact
controller enables advanced process management for
research or cGMP manufacturing.
Key Benefits
•• The single-use vessel eliminates autoclaving and
cleaning, provides rapid turn-around between runs,
reduces risk of contamination, reduces validation
requirements and minimizes initial startup costs
•• The integrated control station enables advanced gas
management and process control
•• Stirred-tank design provides proven performance
and scalability
•• Unique pH and DO technology makes probe insertion
totally noninvasive and autoclaving unnecessary
Single-Use Vessel, Stirred-Tank Design
Interchangeable, rigid-wall, 5 and 14 liter stirred-tank
vessels come pre-sterilized and ready for use — no
cleaning, autoclaving, or assembly needed. All vessel
components in product contact are made of USP
Class VI materials and have been tested for leachables
and extractables, making them appropriate for GMP
environments.
Vessels Include:
•• Bi-directional,
pitched-blade impeller
•• Microsparger
•• pH sensor
•• Tubing (silicone and
C-Flex
®
, for use with
tube welders)
•• 0.2 µm Filters
•• Sealed magnetic drive
Ports and Penetrations:
•• RTD/temperature
•• Noninvasive optical pH
•• Noninvasive
polarographic DO
•• Additions (3)
•• Harvest
•• Overlay
•• Sparge
•• Sampling
•• Exhaust line
with heater
Compact Control Station
New Brunswick’s powerful RPC (Reactor Process Control)
firmware provides integrated control of up to 32 process
parameters, and includes time-saving recipe features,
built-in security and ability to simultaneously monitor up to
eight parameters on user-customized trend graphs.
Sophisticated Control Station includes:
•• Industrial touchscreen interface with adjustable
position, 15” (38 cm) color display
•• 3 integrated pumps (with option to add more)
•• Magnetic-drive motor
•• Control of temperature, pH, DO and 3- or 4-gas
mixing
•• 7 analog inputs and 7 analog outputs for addition of
ancillary devices
•• Media bag hanger
Gas Flow Control Options
•• 1, 3 or 4 Thermal Mass Flow Controllers (TMFC) or a
Rotameter for sparge gas
•• Rotameter or TMFC for optional gas overlay
Additional Options
•• Scale for measuring additions and harvest
•• Validation packages
•• Gas regulators
•• Media/supplement addition kits
•• BioCommand
®
SCADA software
The CelliGen™ BLU Bioreactor: Proven Stirred-Tank Design Meets Single-Use Technology
Ideal•for•research•or•production•environments,•CelliGen•BLU•can•be•
custom-configured•to•meet•your•process•needs.
Single-use,•stirred-tank•vessels•
are•delivered•pre-sterilized•and•
pre-assembled,•ready•for•use•
right•out•of•the•box
14.0•Liter•Vessel 5.0•Liter•Vessel
(2 pages)
(4 pages)
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